A team of researchers led by Professor Yaakov Nahmias, director of the Grass Center for Bioengineering at the Hebrew University of Jerusalem and founder of Tissue Dynamics, introduced a new technological approach that has the potential to rapidly develop new drugs without the need for animal experiments.

Tissue Dynamics Human-on-Chip platform

According to Professor Nahmias, “Drug development is a long and expensive endeavor that is defined by multiple failures. The main reason for this failure is that clinical experiments are ultimately based on minimal information gained from animal experiments which often fail to replicate the human response.”

The primary animals used in drug development are rodents; mice and rats with different genetics, physiology, and metabolism than humans leading to a situation where successful therapies in rodents often fail in clinical trials.

The Hebrew University team developed human-on-a-chip technology, using human tissues in a device, which mimics human physiology. While this type of technology has been in place for over 30 years, Professor Nahmias’s research recently published in the Science Transitional Medicine incorporating microscopic sensors in the human tissue itself enabling the team to precisely monitor the body’s response to specific drug treatments.

“What makes our technology unique is that it allows us to go beyond what was ever possible with animal experimentation. We are now able to insert microsensors that offer us real-time information on how drugs work and when they stop working,” Professor Nahmias says.

Utilizing this new technology, the researchers were able to show that the commonly used cancer drug, cisplatin, causes a dangerous buildup of fat in human kidneys. They were then able to combine this chemotherapy with a different drug, empagliflozin (Jardiance), designed to limit the absorption of sugar in the kidneys, to reduce fatty buildup damage, and minimize kidney damage experienced by cancer patients during therapy.

Drs. Merav Cohen and Aaron Cohen with human kidney microscope

This application represented the first time that the bionic chip was used to develop a drug protocol while avoiding the traditional dependence on animal testing.  “This groundbreaking technology has the potential to significantly reduce the testing and production time for drugs while also avoiding the need to test animals in the lab. This will save time, money, and certainly unnecessary suffering.  Our company Tissue Dynamics continues to develop innovative tools to aid in drug development and we are now moving ahead with clinical testing and working towards regulatory approval of specific drugs as a new way to treat cancer.”

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Citation: Aaron Cohen, Konstantinos Ioannidis, Avner Ehrlich, Shaun Regenbaum, Merav Cohen, Muneef Ayyash,, Sigal Shafran Tikva and Yaakov Nahmias. Science Translational Medicine  24 Feb 2021: Vol. 13, Issue 582, eabd6299
DOI: 10.1126/scitranslmed.abd6299

Funding: European Research Council Consolidator Grant OCL, Nikoh Foundation, Sam and Rina Frankel Foundation.

Abstract: https://stm.sciencemag.org/content/13/582/eabd6299