Achievements

Profiling resistance: A new approach to cancer treatment

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Profiling resistance: A new approach to cancer treatment

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By Diane Hess

Chemotherapy is the most widely-used cancer treatment, and yet in nearly 50% of all cancer cases, drug resistance exists in tumors from the outset. Right now, it takes weeks of treatment before doctors discover that the drugs are ineffective.

According to Professor Nissim Benvenisty, the Chief Scientific Officer at Jerusalem-based biotech NewStem and Director of the Azrieli Center for Stem Cells and Genetic Research at the Hebrew University, “the trial and error period, during which patients experience the harmful side effects of chemotherapy, is taking time away from cancer treatment.”

Professor Benvenisty and his team are testing chemotherapies on a genome-wide library of mutations in human haploid stem cells. Once they complete a database with the results of their work, doctors will be able to submit information on a patient’s tumor genetic profile and predict chemotherapy resistance prior to treatment.

NewStem expects to have its first product on the market within three years, that will address at least one type of chemotherapy for one kind of cancer. The company received $2 million in seed financing in July and will receive an additional $2 million in the next 18 months.

Professor Nissim Benvenisty

Professor Benvenisty began studying human embryonic cells 20 years ago, when the field was brand new. He earned M.D. and Ph.D. degrees from the Hebrew University, and he did his postdoctoral studies at Harvard University.

“One of the advantages of being at the Hebrew University is that we have the strongest student-based biology program in Israel,” said Professor Benvenisty. “We are able to recruit the best students to contribute to our research.”

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