September 25, 2025 – Lifesaving treatment for severe bleeding emergencies can now be rapidly delivered via a new tranexamic acid (TXA) autoinjector device developed by a team including the Hebrew University of Jerusalem (HU).
Severe bleeding is the leading cause of preventable death in trauma situations, from combat zones to highway accidents. TXA—an antifibrinolytic drug known to significantly improve survival in severe bleeding by helping to stabilize blood clots and reduce blood loss—is already widely used in hospitals, trauma centers, and by pre-hospital emergency responders. Research has shown that for every 15-minute delay in administering TXA, its effectiveness drops by 10%, underscoring the need for a faster, simpler solution. However, the standard IV method of administration can be difficult to perform in chaotic, high-stress environments, leading to dangerous delays in treatment.
According to the research published in Injury, the new autoinjector is as effective as traditional intravenous methods, but only takes five minutes and doesn’t require medical expertise. This breakthrough could transform trauma care in emergencies, making rapid, easy-to-administer treatment available in hospitals, roadside accidents, or in military situations when every second counts.
The group of researchers was led by Prof. Arik Eisenkraft and Prof. David Gertz of the HU Faculty of Medicine. The simplicity and portability of the autoinjector device allows it to be used widely by paramedics, first responders, and military medics, ensuring that TXA can be administered within the critical early minutes following severe injury.
“When someone is bleeding heavily, every minute matters,” said Dr. Eisenkraft. “With this autoinjector, even non-medical responders can administer lifesaving treatment almost instantly—and that can mean the difference between life and death.”
“This innovation could transform trauma response in the field,” added Dr. Gertz. “From roadside accidents and natural disasters to combat zones, the ability to deliver a proven treatment quickly and easily has the potential to save countless lives.”
The research paper titled “Autoinjector-Based Delivery of Tranexamic Acid Provides Pharmacokinetic Efficacy in a Porcine Model of Uncontrolled Hemorrhage” is now available in Injury and can be accessed here.
Related articles
Beneath 300 Kilometers: Natural Evidence for Nickel-Rich Alloys in the Mantle
September 26, 2025 – The Earth’s mantle is a restless, enigmatic engine that powers volcanism, recycles crust, and regulates the long-term evolution of the planet. However, one of its most elusive characteristics—the redox state, or the balance of oxidized and reduced chemical
New Experiment May Aid in the Search for Lightweight, Dark Matter Particles That Have Eluded Scientists
September 26, 2025 – A new experiment using superconducting detectors cooled to near absolute zero opens an entirely new frontier, testing the existence of extremely light dark matter particles, with masses thousands of times smaller than those probed by previous experiments. Dark matter,
Record Room Temperature Photon Collection from Diamonds Achieved in New Quantum Breakthrough by Hebrew University Researchers
September 25, 2025 – A new breakthrough in capturing up to 80% of photons from tiny diamond defects at room temperature achieves a necessary step for quantum technology development. In the article published in APL Quantum, researchers from the Hebrew University of Jerusalem (HU) and the
